- A meta-analysis suggests that vasectomy reversal does not provide protection against prostate cancer; no causal relationship between vasectomy and prostate cancer could be established.
Why this matters
- Studies reporting small or no risk for prostate cancer in vasectomized men are criticized for detection bias.
- If vasectomy increases the risk for prostate cancer, then the risk would be lower in men who subsequently undergo vasectomy reversal.
- This meta-analysis compared data of 9754 men with vasectomy reversal and 684,660 men who underwent vasectomy but no reversal across 5 regions.
- Funding: None.
- Median follow-up in vasectomy-only cohort was 7-21 years and in vasectomy-reversal cohort was 7-19 years.
- Median time to vasectomy reversal was 4-7 years.
- The combined risk for prostate cancer was similar between both groups (HR, 0.92; 95% CI, 0.70-1.21; no heterogeneity).
- Details of screening, levels of healthcare provider engagement were unknown.
- Not all vasectomies and vasectomy-reversal procedures were included.