Takeaway
- An intensive 2-year lifestyle intervention program for moderate weight loss was associated with increased DFS in program completers, according to data from the phase 3 SUCCESS C trial.
Why this matters
- Obesity and reduced physical activity are associated with increased breast cancer incidence, increased recurrence, and decreased survival.
Study design
- 2292 women with breast cancer and a BMI ≥24 kg/m2 were randomly assigned after chemotherapy to receive either general healthy lifestyle advice through mailings/newsletters (n=1146) or personalized telephone- and mail-based guidance aimed at long-term moderate weight loss (n=1146).
- Multivariable aHRs were adjusted for age, BMI, menopausal status, tumor size, nodal stage, HR status, grading, histological type, and chemotherapy randomization.
- Funding: Chugai; GlaxoSmithKline; Janssen Diagnostics; Pfizer; Sanofi-Aventis.
Key results
- Median follow-up, 64.2 months.
- Women in the intervention group lost a mean 1 kg (n=828) compared with a mean 0.95 kg gain in control patients (n=816; P
- Intent-to-treat analysis showed no difference in DFS (HR, 0.99 [P=.922]; aHR, 0.91 [P=.48]) or OS (P=.799).
- 1477 patients completed the program.
- Intervention completers (n=552) had significantly greater DFS than noncompleters (n=594; HR, 0.35; P<.001>
- Intervention completers had significantly greater DFS than control group completers (n=925; HR, 0.53 [P=.004]; aHR, 0.51 [P=.002]).
Limitations
- Low adherence to intervention.
- Low number of events.
- Study completers may have had greater motivation.
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