Pediatric DTC: stimulated post-op thyroglobulin predicts persistent disease

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Takeaway

  • Stimulated postoperative thyroglobulin (sPOTg) is associated with persistent disease in children and adolescents with differentiated thyroid cancer (DTC).

Why this matters

  • Prognostic factors are needed for pediatric patients with DTC to guide treatment.

Key results

  • 100% of patients underwent total thyroidectomy, 90.6% received radioactive iodine therapy.
  • After a median follow-up of 5 y, 55.6% of patients were disease free, 22.2% had biochemical disease, and 22.2% had persistent structural disease.
  • Lymph node metastasis at diagnosis (P=.003), distant metastasis at diagnosis (P=.010), and sPOTg (P<.001) were associated with persistent disease in univariate analysis.
  • A cutoff of 31.5 ng/mL sPOTg had sensitivity and specificity of 100% for predicting disease-free status.

Study design

  • 32 patients with DTC aged ≤18 y were analyzed for clinicopathology associated with disease status, including sPOTg.
  • Funding: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Fundo de Incentivo a Pesquisa and Programa de Apoio a Núcleos de Excelência/Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul.

Limitations

  • Small patient sample size.
  • Only 17 patients analyzed for sPOTg and disease status at follow-up.