OSCC survival linked to skeletal muscle mass

  • Chargi N & al.
  • Oral Oncol
  • 16 déc. 2019

  • Par Brian Richardson, PhD
  • Résumés d'articles
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Takeaway

  • Sarcopenic obesity (low skeletal muscle mass [SMM] with obesity) on imaging is associated with poor survival outcomes of patients with oropharyngeal squamous cell carcinoma (OPSCC).

Why this matters

  • SMM is an emerging prognostic factor in oncology, but its utility in OPSCC was unknown.

Key results

  • 64.8% of patients had low SMM (≤43.0 cm2/m2 for OS; ≤43.2 cm2/m2 for DFS).
  • 6.0% of patients had sarcopenic obesity.
  • Low SMM alone was not significantly associated with OS or DFS in multivariate analysis.
  • Sarcopenic obesity was associated with reduced OS (HR, 4.42; P<.01 and dfs p=".04)" in multivariate analysis.>
  • High-risk status (human papillomavirus-negative status with ≥10-pack-years of smoking or T4-stage) was also associated with reduced OS (HR, 2.93; P<.01 and dfs p>

Study design

  • 216 patients with OPSCC were radiologically analyzed for SMM and its associations with survival outcomes.
  • Funding: None disclosed.

Limitations

  • Retrospective study.