- Sarcopenic obesity (low skeletal muscle mass [SMM] with obesity) on imaging is associated with poor survival outcomes of patients with oropharyngeal squamous cell carcinoma (OPSCC).
Why this matters
- SMM is an emerging prognostic factor in oncology, but its utility in OPSCC was unknown.
- 64.8% of patients had low SMM (≤43.0 cm2/m2 for OS; ≤43.2 cm2/m2 for DFS).
- 6.0% of patients had sarcopenic obesity.
- Low SMM alone was not significantly associated with OS or DFS in multivariate analysis.
- Sarcopenic obesity was associated with reduced OS (HR, 4.42; P<.01 and dfs p=".04)" in multivariate analysis.>
- High-risk status (human papillomavirus-negative status with ≥10-pack-years of smoking or T4-stage) was also associated with reduced OS (HR, 2.93; P<.01 and dfs p>
- 216 patients with OPSCC were radiologically analyzed for SMM and its associations with survival outcomes.
- Funding: None disclosed.
- Retrospective study.