- Tumor spread through air spaces (STAS) is associated with worse recurrence-free survival (RFS) and OS in patients with stage 1A NSCLC undergoing sublobar resection (SR).
- STAS was not a prognostic factor with lobectomy.
Why this matters
- STAS has recently been identified as a risk factor for poor prognosis, but little is known about its prognostic effect by resection type.
- Patients with stage 1A NSCLC underwent lobectomy (n=634) or SR (n=118).
- Funding: Shanghai Hospital Development Center; Fundamental Research Funds for the Central Universities; and others.
- 28.7% of the lobectomy group and 36.4% of the SR group had STAS.
- STAS was associated with worse RFS and OS in SR patients (HR, 3.529 [P<.001 and hr but not in lobectomy patients p=".052," respectively>
- STAS was more likely in patients with micropapillary predominant adenocarcinoma (P<.001 and a tumor-margin distance of cm>
- Patients with disease in the T1c category had a significantly higher risk for STAS in residual lung segments (HR, 5.868; P=.033).
- In residual lung segments, STAS occurred in 9 of 100 simulated cases.
- Retrospective, single-center study.