Major salivary gland carcinoma: lymph node density predicts outcomes in patients without lymph node metastasis

  • Terada H & al.
  • Am J Otolaryngol
  • 5 oct. 2019

  • Par Brian Richardson, PhD
  • Résumés d'articles
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Takeaway

  • Higher lymph node density (LND) is associated with reduced OS in patients with major salivary gland carcinoma without clinical lymph node metastasis (LNM).

Why this matters

  • Prognostic factors in this rare cancer type are poorly understood.

Key results

  • 3-year OS was 85.6%, 3-year DFS was 78.4%, 3-year locoregional relapse-free survival was 90.1%, and 3-year distant metastasis-free survival was 80.2%.
  • pN2-3 status (HR, 5.44; P=.046) and positive surgical margins (HR, 5.29; P=.03) were associated with reduced OS.
  • LND ≥0.1 was associated with reduced OS (HR, 12.94; P=.019) in multivariate analysis.

Study design

  • 60 patients with major salivary gland carcinoma without clinical lymph node metastasis, 50 who underwent neck dissection, were included.
  • Funding: JSPS KAKENHI.

Limitations

  • Retrospective study.
  • Small patient sample size.