- Higher lymph node density (LND) is associated with reduced OS in patients with major salivary gland carcinoma without clinical lymph node metastasis (LNM).
Why this matters
- Prognostic factors in this rare cancer type are poorly understood.
- 3-year OS was 85.6%, 3-year DFS was 78.4%, 3-year locoregional relapse-free survival was 90.1%, and 3-year distant metastasis-free survival was 80.2%.
- pN2-3 status (HR, 5.44; P=.046) and positive surgical margins (HR, 5.29; P=.03) were associated with reduced OS.
- LND ≥0.1 was associated with reduced OS (HR, 12.94; P=.019) in multivariate analysis.
- 60 patients with major salivary gland carcinoma without clinical lymph node metastasis, 50 who underwent neck dissection, were included.
- Funding: JSPS KAKENHI.
- Retrospective study.
- Small patient sample size.