- Patients with lymphoma are at increased risk of developing herpes zoster (HZ).
- Prophylaxis should be considered, especially in those with risk factors identified in the study.
Why this matters
- Patients with cancer are at increased risk of developing HZ; patients with hematologic malignancies are at greater risk than patients with solid tumors.
- Study to identify risk factors for developing HZ in 415 adult patients with lymphoma.
- Data were sourced from the Auxilio Mutuo Cancer Center (AMCC) registry.
- Median patient age at diagnosis, 67 years.
- Funding: National Center for Minority Health and Health Disparities; National Institutes of Health.
- 46 cases of HZ identified at 8.9 years' median follow-up.
- Increased HZ incidence was associated with factors including:
- multiple chemotherapy courses (P=.035),
- stage at diagnosis (advanced vs localized; P=.034),
- presentation (indolent vs aggressive; P=.030),
- highly immunosuppressive chemotherapy (with vs without; P<.001 and>
- lymphocytopenia (defined as baseline absolute lymphocyte count
- Patients with mild symptoms of HZ may not have been identified.
- Retrospective data.