- A retrospective, population-based study suggests that chemoradiotherapy (CRT) is associated with similar rates of distant metastasis as RT alone in most patients with HPV-positive/negative oropharyngeal squamous cell carcinoma (OPSCC).
Why this matters
- Distant metastasis is the leading cause of death in patients with OPSCC.
- 11.4% of patients developed distant metastases.
- T3 status (HR, 2.898; P=.0216), N2 status (HR, 2.651; P=.0112), and N3 status (HR, 7.949; P=.0034) were associated with risk for distant metastasis.
- HPV-positive status was inversely associated (HR, 0.357; P=.0007) with risk for distant metastasis.
- RT and CRT were associated with similar risk for distant metastasis (HR, 1.152; P=.6363).
- HR, 0.894 (P=.7697) in HPV-positive patients
- CRT did not reduce the risk for distant metastasis in HPV-negative patients (HR 1.82, 95% CI 0.65-5.07).
- In HPV-positive patients, T4 status (HR 4.121, P=.280) and high-risk status (HR 2.800, P=.0106) were associated with risk for distant metastasis.
- 525 patients with OPSCC were analyzed for associations among HPV status, treatment modality, and rates of distant metastasis.
- Funding: Canadian Institutes of Health Research; Canadian Cancer Society Research Institute.
- Location of distant metastasis not included in analysis.
- Retrospective study.