- A retrospective study finds 64.5% recurrence-free survival (RFS) following primary surgery for locally aggressive head and neck basal cell carcinoma (BCC), with intraoperative positive frozen section margin, a strong predictor of local recurrence.
Why this matters
- Locally aggressive BCC of the head and neck is rare and poorly studied.
- 5-year estimated RFS was 64.5%, OS was 83.3%, and disease-specific survival was 98.3%.
- Intraoperative positive frozen section margin (28.6% of tumors) was independently predictive of local recurrence (HR, 6.88; P=.038).
- Tumors previously treated with radiation (14.3%) were more likely to have intraoperative positive frozen section margins (OR, 6.47; P=.05).
- 87 patients with BCC of the head and neck (98 total tumors) were treated with primary surgical resection and analyzed for outcomes and associated outcomes.
- Funding: None.
- Retrospective study design.
- Small patient sample size.