CRC: BMI shows little utility for assessing cardiovascular risk

  • Brown JC & al.
  • JAMA Oncol
  • 16 mai 2019

  • Par Jim Kling
  • Résumés d'articles
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Takeaway

  • Body composition as assessed by visceral adiposity and muscle radiodensity, but not BMI, was associated with cardiovascular disease risk in patients with colorectal cancer (CRC).

Why this matters

  • Existing guidelines recommend BMI for assessing body composition in patients with CRC, but this is based on expert opinion.

Study design

  • Retrospective study (n=2839; 1455 women).
  • Funding: National Cancer Institute.

Key results

  • Median follow-up, 6.8 years; major adverse cardiovascular events (MACE), 12.9% participants.
  • No association between BMI and risk for MACE (BMI, >35 vs 18.5-24.9 kg/m2; HR, 1.23; Ptrend=.50).
  • Risk for MACE was greater in the highest quintile of visceral adipose tissue area vs the lowest quintile (HR, 1.54; Ptrend=.04).
  • No association between muscle mass and risk for MACE (highest to lowest quintile; HR, 0.96; Ptrend=.92).
  • Risk for MACE was lower in the highest quintile of muscle radiodensity (less lipid stored in muscle) compared with the lowest quintile (more lipid; HR, 0.67; Ptrend=.02).

Limitations

  • Retrospective study.