- Receipt of neoadjuvant chemotherapy vs receipt of postoperative chemotherapy is associated with fewer reoperations after lumpectomy for breast cancer.
Why this matters
- Reoperation is common, with more than 1 in 5 patients treated with lumpectomy undergoing reoperation for perceived residual disease.
- 71,627 patients with stages I-III breast cancer in the National Cancer Database (NCDB) were evaluated for type of chemotherapy and reoperation rates (RORs) using multivariable logistic regression modeling.
- Funding: Gundersen Medical Foundation, Norma J. Vinger Center for Breast Care, University of Wiscosin La Crosse.
- The RORs were 11.4% for those who received neoadjuvant chemotherapy vs 20.3% for those who received postoperative chemotherapy (unadjusted OR=0.53; P<.001).
- The ORs for reoperations for patients with stage 1 cancer was 0.65 (P<.001), with stage II cancer was 0.50 (P<.001), and with stage III cancer was 0.27 (P<.001).
- There was some missing data for ROR because the NCDB does not have a field for ROR.