Advanced NSCLC: psychosocial factors may play a role in progression, mortality

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  • Higher levels of anxiety after NSCLC diagnosis were associated with a greater risk for lung cancer-specific and all-cause mortality.

Why this matters

  • Psychological distress should be considered when evaluating patients at diagnosis and as part of overall disease management.

Study design

  • Population-based study including 684 patients diagnosed with stage III lung cancer at 2 cancer centers who were routinely assessed for anxiety and depression with the PsychoSocial Screen for Cancer (PSSCAN) questionnaire after diagnosis and before beginning treatment.
  • Funding: None disclosed.

Key results

  • In unadjusted analyses, there were significant associations between anxiety and all-cause mortality (Χ2(1)=4.31; P=.038) and depression and lung cancer-specific (Χ2...