- The level of depressive symptoms in an older adult population is associated with a heightened risk of ischemic stroke during follow-up.
Why this matters
- Elevated depressive symptoms were common in these older adults and were associated with a 75% increased ischemic stroke risk.
- 198/1104 (18%) participants, Center for Epidemiological Studies–Depression Scale (CES-D) ≥16.
- At baseline, more depressive symptoms in women (P<.0001 and hispanics>
- At mean 11 years follow-up, cumulative stroke incidence of 13%: CES-D
- Models controlling for sociodemographic, health behavior, or cardiovascular risk factors produced adjusted HRs of ischemic stroke for CES-D ≥ vs
- MRI substudy of the Northern Manhattan Study conducted in New York and Miami.
- Community-dwelling adults ≥55 years of White, Black, or Hispanic ethnicity.
- Stroke-free at baseline.
- Self-reported depressive symptoms on CES-D (≥ vs
- Funding: National Institute of Neurological Disorders and Stroke and American Heart Association/American Stroke Association.
- Relatively small sample size and stroke incidence.
- Observational study does not suggest a causal association.
- Lead author Marialaura Simonetto said the effect of treatment for depression has not yet been analyzed.