- 1-view digital breast tomosynthesis with reduced compression force showed higher sensitivity and slightly lower specificity vs conventional 2-view digital mammography in the large Swedish cohort study, the Malmo Breast Tomosynthesis Screening Trial (MBTST).
- This led to a 34% higher breast cancer detection rate, accompanied by a higher recall rate.
Why this matters
- Tomosynthesis had mostly better diagnostic features with the potential for radiation dose reduction and lower screen-reading burden.
- Population-based, prospective screening study of 14,851 women aged 40-74 years who received both screening methods.
- Each screening method was read by a committee of 7 masked radiologists, and results were compared with surgery, core-needle biopsy, or medical records.
- Funding: Swedish Cancer Society; Swedish Research Council; Breast Cancer Foundation.
- Tomosynthesis (vs conventional mammography) had higher sensitivity (81.1% [95% CI, 74.2%-86.9%] vs 60.4% [95% CI, 52.3%-68.0%], respectively; no P-value given) yet slightly lower specificity (97.2% [95% CI, 97.0%-97.5%] vs 98.1% [95% CI, 97.9%-98.3%]; no P-value given).
- Tomosynthesis had a 34% higher cancer detection rate per 1000 women screened (8.7 vs 6.5; P<.0001>
- Tomosynthesis had higher recall rate (3.6% vs 2.5%; P<.0001>
- Tomosynthesis has limitations for dense breasts.
- Single-institution study.